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The present invention is based at least in part on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody

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Oct 08 2009The present invention features inter alia polypeptides comprising an Fc region comprising genetically-fused Fc moieties In addition the instant invention provides e g methods for treating or preventing a disease or disorder in subject by administering the binding polypeptides of the invention to said subject

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neopentyl glycol diglycidyl ether acid cream

NEOPENTYL GLYCOL DIETHYLHEXANOATE - EWG About EWG VERIFIED™ Beyond providing Skin Deep as an educational tool for consumers EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria

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Jun 28 2007RELATED APPLICATIONS This application is a continuation application of International Patent Application No PCT/US2004/037929 filed Nov 12 2004 titled "NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO" which claims the benefit of U S

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What Do Nitrogen Phosphorus and Potassium Fertilizers Do Any fertilizer you buy will have a ratio of three compounds listed such as 5-5-5 The numbers represent the N-P-K ratio—the available nitrogen (N) phosphorus (P) and potassium (K) contained in that fertilizer

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Methods of Humanizing Immunoglobulin Variable Regions

Patent application title: Methods of Humanizing Immunoglobulin Variable Regions Through Rational Modification Of Complementarity Determining Residues Inventors: Alexey Alexandrovich Lugovskoy (Woburn MA US) Alexey Alexandrovich Lugovskoy (Woburn MA US) Karl Hanf (Billerica MA US) You Li (Newton MA US) Kenneth Simon (Cambridge MA US) Herman

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